There are many reasons for a sudden and very sore throat overnight, such as environmental factors, bacterial infections, viral infections, and so on. 1. Environmental factors: cold and dry weather, open-mouth breathing during sleep, etc., can cause dryness and pain in the throat. 2. Bacterial infections: Tonsillitis, pharyngitis, epiglottitis and other diseases induced by bacterial infections can also lead to the phenomenon of a sudden sore throat overnight, accompanied by symptoms such as dry pharynx, pharyngolaryngolaryngolaryngolaryngolaryngitis, swallowing obstruction and even respiratory disorders. 3. Viral infections: viral infections can induce herpetic pharyngitis, so the phenomenon of a sudden sore throat overnight, with the development of the disease, the later stages of the throat will also appear single or multiple herpes. There are many reasons for the sudden pain in the throat overnight, and after the symptoms, it is recommended to go to the hospital in time to improve the examination and clear diagnosis, and take standardized treatment according to the doctor’s instructions, and not to delay the condition, delaying the treatment of the condition.