Husband has thalassemia and wife has resting thalassemia, such pregnancy may have effect on the baby, genetic counseling must be done before pregnancy. If both husband and wife belong to thalassemia minor patients, there is a certain chance to give birth to a baby with thalassemia major. If between the two husband and wife, only one of them is a thalassemia minor patient or a thalassemia gene carrier, the chances of the child being normal are higher, but there are also some children who belong to the thalassemia minor gene carriers, and they usually do not suffer from thalassemia major. It is recommended that the patient and couple need to go to a regular hospital to receive prenatal examination first, and the specialist doctor will analyze the results according to the examination. In addition, thalassemia is a more dangerous disease, if both husband and wife are thalassemia patients, they need to be careful about having children and must do genetic counseling.