The increase of lesions after chemotherapy for lung cancer can be changed by chemotherapy regimen, surgery, radiotherapy or targeted therapy. 1. Changing chemotherapy regimen: the increase of lesions after chemotherapy for lung cancer indicates that tumor cells are less sensitive to drugs, so chemotherapy regimen can be changed and radiotherapy can be added at the same time. 2. Surgery: Surgical resection is the first choice and the main treatment method for lung cancer, as long as it meets the criteria of surgery, surgery should be chosen as much as possible. 3. Targeted therapy: Targeted therapy is highly targeted and has better curative effect on tumor with mild side effects. Ineffective chemotherapy can try to use targeted therapy, but it needs to be decided according to the results of genetic test. After chemotherapy for lung cancer, the lesion should be enlarged in time to go to the hospital for follow-up, and the doctor should choose the next treatment plan according to the examination results.