According to the World Health Organization, physical inactivity has become the fourth leading risk factor for death worldwide. It is estimated that physical inactivity kills up to 3.2 million people worldwide each year, with rapid growth in the last decade. The convenience and high pace of modern lifestyle has led to a lack of physical activity is a common phenomenon. Some people don’t think it’s a problem and feel that moving around is all about them. In fact, this is not only a personal problem, but can also cause serious social problems. This is because lack of physical activity is associated with numerous adverse health events, including total mortality, cardiovascular morbidity and mortality, and stroke risk, which is likewise a huge burden on social health insurance and public health resource utilization. Let’s focus today on the relationship between physical inactivity and stroke. One study found that physically active men and women typically have a 25% to 30% lower risk of stroke or death compared to those who are physically inactive. Physical activity comes in a variety of forms, including general recreational physical activity, professional physical activity at the athlete level, and even walking, all of which have good benefits. In several athlete health studies, adequate physical activity has been found to be associated with a reduced incidence of stroke in both men and women. So how does physical activity play a protective role? To some extent, by lowering blood pressure and reducing other cardiovascular disease risk factors such as diabetes and obesity, among other effects. In addition, physical activity reduces plasma fibrinogen and platelet activity and increases plasma tissue fibrinogen activity and the concentration of HDL cholesterol, the “good cholesterol” in the blood. Physical activity may also have positive health effects by increasing anti-inflammatory cytokines in the blood (e.g., interleukin-1 receptor antibodies and interleukin-10) and other regulatory immune pathways. Therefore, to prevent stroke, healthy adults should engage in moderate- to vigorous-intensity aerobic physical activity for at least 40 min per day, 3 to 4 days per week. Let’s get moving!