A plus sign for urine protein indicates recent kidney damage, or chronic kidney damage, because in some cases of acute glomerulonephritis, positive urine protein can occur. Patients on a large protein diet will have transient proteinuria, or some adolescents will have transient proteinuria after strenuous exercise; these are physiological proteinuria with no damage to the kidneys themselves. For chronic kidney diseases, such as chronic glomerulonephritis, kidney failure, diabetic nephropathy, hypertensive kidney damage, all have protein in the urine, and some treatments are not effective. The aim of treatment is to reduce the damage to the kidney by urine protein and delay the progress of kidney disease. If the primary disease is actively treated, such as controlling blood pressure and blood sugar, some patients need to apply hormone therapy to slow down the progress of the disease and preserve the residual kidney function.