Pain in the buttocks and legs 15 days after minimally invasive lumbar protrusion surgery can be treated with rest, physical therapy, and medication. If the pain is significantly worse than before surgery, further examination is needed. Lumbar disc herniation may still be in the recovery stage if the disease is long and the nerve compression is obvious, and there is still pain in the buttocks and legs 15 days after the operation. Patients should pay attention to rest and wear a waist immobilization belt to reduce the pressure on the lumbar spine. The lumbar region can choose hot compresses and massage to improve blood circulation and promote the absorption of inflammatory substances to relieve symptoms. Oral anti-inflammatory and analgesic drugs can also be taken for anti-inflammation and pain relief, such as nimesulide and diclofenac sodium, as well as neurotrophic drugs such as methylcobalamin and adenosylcobalamin. If the pain in the buttocks and legs is significantly worse than before surgery 15 days after the minimally invasive lumbar spine surgery, it is necessary to undergo further examination under the guidance of the doctor to exclude the possibility of incomplete surgical decompression as well as nerve injury, and to take further treatment according to the cause.