Both thighs have a red pimple phenomenon, consider and perifollicular keratosis, folliculitis, mosquito bites, can choose to use urea cream, topical antibiotic drugs, glucocorticoids and other drugs. 1. Keratosis pilaris: a chronic follicular keratosis skin disease, may be related to genetic factors, vitamin A deficiency, generally do not need special treatment, will not affect their own health, if conscious of the impact on the aesthetics of the external urea cream, salicylic acid ointment and other drugs. 2. Folliculitis: two thighs have a red pimple may also be related to folliculitis, there will be a hair follicle as the center of the red pimples accompanied by itchy and painful symptoms, and bacterial infections related to the choice of topical fusidic acid cream, mupirocin ointment and other antibiotic treatment. 3. Mosquito bites: generally occur in the hot summer, mosquitoes more places, mosquito bites, there will be a red pimple on the thigh, accompanied by itching performance, you can choose to use topical glucocorticoid drugs, such as mometasone furoate gel, etc., can play an anti-inflammatory and anti-itching effect. Both thighs have a red pimple situation, there may be other reasons, need to cooperate with the doctor to improve the relevant examination, to determine the cause, and then do targeted treatment, the specific use of drugs need to comply with medical advice.