Introduction: The principle of treatment of pathological jaundice in newborns is, first of all, to identify the cause and carry out etiologic treatment, which is the root of treatment, and only after eliminating the cause can we prevent recurrence. The second is to give light therapy (hereinafter referred to as phototherapy) as soon as possible. Studies have shown that bilirubin can absorb light, and light irradiation can accelerate the oxidative decomposition of free bilirubin, promote the clearance and excretion of bilirubin, reduce the concentration of serum unconjugated bilirubin, and prevent the occurrence of nuclear jaundice. Therefore, when the serum bilirubin is higher than 205 micromol/liter in full-term infants; higher than 85 micromol/liter in ultra-low birth weight infants; and higher than 103 micromol/liter in very low birth weight infants, it is an indication for phototherapy. During phototherapy, the newborn is placed naked in the phototherapy box, and the eyes and perineum are covered with black cloth and irradiated with single or double light. There are many considerations for phototherapy, mainly including: 1. The duration of phototherapy is generally set at 24 to 48 hours, and should not exceed 3 days; 2. The decrease in serum bilirubin concentration should be the basis. Because phototherapy mainly affects the superficial skin tissue, jaundice does not mean that the serum bilirubin has also been normal; 4, phototherapy does not affect breastfeeding, and the newborn can be carried out regularly for feeding. In order to facilitate breastfeeding, the phototherapy box can be placed next to the mother’s bed, and medical personnel should regularly observe and care for the baby; 5, the side effects of phototherapy are relatively few, the child may occasionally appear fever, diarrhea and rash, but they are not serious and will not affect the continued treatment; 6, because the newborn is placed naked in the phototherapy box, there is a lot of space for activity, and it is easy to rub the skin, so the newborn’s skin must be checked for damage after the completion of phototherapy to prevent secondary infection. So that timely treatment to prevent secondary infection.