Pediatric rectal drug delivery has its advantages and disadvantages, and there is a certain amount of controversy in the current treatment, the specific situation should be analyzed. Rectal drug delivery is mainly for pediatric patients who are unable to take oral medication for treatment, who are very laborious to take medication, or who are particularly difficult to find blood vessels when taking intravenous infusion, and who cannot be treated with intravenous infusion can consider rectal drug delivery. Rectal administration is a treatment method in which the drug is diluted and pushed into the rectum and absorbed through the rectal vein. However, this method is suitable for children with poor gastrointestinal function, such as diarrhea or constipation, if the rectal administration of drugs will lead to the imbalance of intestinal flora, easily leading to the child’s existing indigestion, diarrhea or constipation symptoms aggravated, so the specific situation should be analyzed.