Schizophrenia is a more serious chronic psychotic disorder that is prone to relapse, and generally requires a consolidation and maintenance period of antipsychotic medication after complete control of psychotic symptoms. Most patients will develop depressive symptoms within 2-6 months after the control of psychotic symptoms, at which time they should be treated with antidepressant medication. During the whole treatment process, doctors should provide psychological cognitive therapy to patients, so that they can gradually understand the nature of their illness, the necessity of insisting on medication, the benefits brought to patients, so that patients can see the hope of cure, the possibility of continuing to work and study, and establish confidence in overcoming the disease, and at the same time, face the reality, treat themselves and the disease well, and adapt to society, family, and work and study again. Doctors should also pay attention to protecting patients’ privacy and improving patients’ compliance with treatment. However, long-term medication will bring economic and mental pressure to patients, so doctors should always maintain communication with patients, timely detection of problems, such as adverse drug reactions, side effects, patients can not bear the economic pressure, etc., timely adjustment of drugs and doses, so that treatment should not be easily interrupted, long-term maintenance treatment as far as possible to make the drug dose in the minimum dose of symptom control, but must depend on the specific condition If the dosage is too small, it will lead to relapse of psychotic symptoms, and if the dosage is too large for a long time, it will lead to poor compliance and side effects.