Patients who develop vaginal itching are not the typical clinical features of HIV manifestations. After high-risk sex, if a patient is infected with AIDS, usually about one month after HIV infection, he or she will develop flu-like symptoms, such as headache, fever, sore throat, weakness, diarrhea, and swollen lymph nodes, and at this time vaginal itching does not occur directly. The main clinical manifestations of the disease when the patient enters the onset of AIDS are also characterized by a variety of conditional infections and tumor development, and vaginal itching is not the main clinical manifestation at this stage. If a patient has significant vaginal itching after high-risk sex, it is important to consider whether it is a case of mycosis vaginalis, trichomoniasis, bacterial vaginitis or other STDs, and suggest that the patient seek timely medical attention from the gynecology department of a regular hospital.