Migraine, also known as “migraine headache”, is a vascular neurological headache, mostly seen in young adults. The headache often starts from the temporal region, orbit or forehead and gradually expands to half of the head, or the whole head. The disease is often recurrent and lingering, and the patient is in great pain. In my clinical work for more than 20 years, I have formulated my own medicine to disperse migraine and relieve pain to treat 60 cases of headache with satisfactory results. The above medicines are decocted in water, one dose per day, and the second decoction is evenly distributed in the morning and evening, one month is a course of treatment. Discussion: “If it does not pass, it hurts.” According to traditional Chinese medicine, migraine is mostly caused by mental irritation and liver qi depression, liver depression turns into fire, and fire produces wind, and wind and fire disturb the clear orifices and hurt the brain liao and cause pain, and the disease enters the liao for a long time, stagnates qi and blood, and causes severe headache. The head is the meeting of all the yang and the sea of marrow, the blood of the essence of the five viscera and the qi of the six viscera is injected into the head. Migraine can occur when the evil of the six sexes is committed to the top of the head, stasis of blood in the head or loss of nourishment in the brain. Modern medicine considers migraine as a periodic headache syndrome, which is caused by the dysfunction of neurons, especially hypothalamic neurons, resulting in disorder of vasodilation and contraction. In this formula, Chuanxiong and Fangfeng dredge liver and Qi, invigorate blood circulation, dispel wind and relieve pain; Chaihu and Xiangxian move Qi and open depression to regulate Qi; Manchuria clears head and eyes and is good at treating head wind; Danshen invigorates blood, moves blood and nourishes blood and invigorates blood circulation; Xuanhu invigorates blood and facilitates Qi as a good medicine to relieve pain; Sanguisorba and Dilong clear heat and extinguish wind circulation; Chrysanthemum clears heat and detoxifies, clears head and eyes; Angelica dahurica and Qiangwu move head and eyes, clear wind and relieve pain; Paeonia lactiflora is sour and bitter, fears cold, nourishes blood and astringes yin, softens liver and relieves pain; San Qi is a good medicine to relieve pain. It can soothe the liver and relieve pain; Panax ginseng powder can invigorate the blood to relieve pain and relieve headache; licorice can relieve pain and harmonize all the medicines. The combination of all the herbs together can dredge the liver, invigorate blood and dispel wind, clear heat and open the orifices to relieve pain, which is effective in the treatment of migraine.