There are some differences between compound azinomide and trimethoprim in terms of indications, contraindications and adverse reactions. 1. Indications: compound azinamid can be used to treat symptoms caused by digestive enzyme deficiency or insufficient bile secretion; trimethoprim can be used to treat nausea, vomiting, loss of appetite, abdominal distension, belching and other symptoms caused by gastrointestinal motility disorders, as well as irritable bowel syndrome. 2. Contraindications: Azinamide should not be used in patients with hepatic dysfunction, bile duct obstruction, acute hepatitis, biliary colic due to cholelithiasis; Trimethoprim should not be used in people who are allergic to trimethoprim. 3. Adverse reactions: Cotrimoxazole has not been seen serious adverse reactions; Trimethoprim may be numbness in the mouth, abdominal ringing, thirst, diarrhea, constipation, as well as dizziness, tachycardia, skin rash, drowsiness and other symptoms. Patients who need to be treated with compound azinamid or trimethoprim should take it under the guidance of a doctor and should not use it without authorization.