There is no such thing as the most effective treatment for chloasma. Generally speaking, it is necessary to combine various treatments to achieve better therapeutic effect, and the treatments include avoiding triggering factors, medication, laser treatment and so on. 1. Avoid triggering factors: To treat chloasma, first of all, we should avoid triggering factors, otherwise everything will be ineffective. For example, avoid taking hormone level changes and photosensitive drugs, avoid staying up late at night, avoid mental tension and anxiety, pay attention to sunscreen when going out, and actively treat diseases that may induce chloasma, such as certain gynecological diseases and liver diseases. 2. Medication: Medication includes topical hydroquinone cream, compound arbutin cream, etc. Meanwhile, oral vitamin C and vitamin E, tranexamic acid, etc., which can make chloasma fade away or disappear gradually, and the medicines should be used under the guidance of professional doctors, avoiding self-medication. 3. Laser treatment: Laser treatment is suitable for patients with stubborn melasma, such as intense pulse light, picosecond, etc. Laser treatment adopts specific light wave to directly act on melanin to destroy and decompose it, and when the pigment is gradually absorbed by human body, the color will be faded. Chloasma is prone to recurrence, so it is necessary to follow the doctor’s prescription to use medication to control and relieve the condition. Patients who apply medication for a long period of time should pay attention to the observation of the efficacy and adverse reactions, and inform the doctor in time once any discomfort occurs.