Ulcerative colitis with colonic ulcers can first be treated conservatively with medication, using anti-inflammatory drugs and immunosuppressants, if the time is long without improvement, it is recommended to do surgical resection and intestinal anastomosis.
1.Medication:
(1) Control of inflammation: 5-aminosalicylic acid can inhibit prostaglandin synthesis and the formation of inflammatory mediator leukotriene in the intestinal mucosa, and it has significant anti-inflammatory effect on intestinal inflammation. Commonly used drugs such as mesalazine.
Acute exacerbation as well as 5-aminosalicylic acid is not effective in mild and moderate patients, especially for patients with severe, available prednisone has a better efficacy.
(2) Symptomatic treatment: for patients with electrolyte disorders, timely correction of water and electrolyte balance disorders; anemia can be transfused; hypoproteinemia should be supplemented with albumin.
(3) Antibiotics: antibiotics such as levofloxacin, cephalosporin antibiotics, metronidazole, etc. can be used concurrently for combined bacterial infections.
(4) Immunosuppressants or biological agents such as infliximab, vedolizumab, etc.
2. Surgical treatment: For those who have unsatisfactory results of internal medicine treatment and seriously affect the quality of life, total colectomy plus ileoanal pouch anastomosis can generally be used.
Ulcerative colitis with colonic ulcers should be early medical care, clear cause, cause-specific treatment, standardized treatment under the guidance of a physician to reduce the adverse effects of the disease, to avoid self-medication and delay the condition.