This disease is one of the most serious complications of diabetes. Patients with this disease are often associated with large artery occlusion and toe ulcers. These toe ulcers are sensible gangrene; if the patient does not have arterial occlusion, he or she will have ulcers on the edges, soles, and backs of the feet, which are wet gangrene. Patients with diabetes mellitus who have perceptual nerve disorders and pain or temperature paralysis should pay special attention to prevent burns and trauma to avoid gangrene. 1.Adopt dietary control and medication to strictly control diabetes, so that the blood sugar is close to the normal level, and avoid the occurrence of hypoglycemia. 2. Local surgical treatment. Local debridement of gangrene, the application of antibacterial and improve microcirculation drugs. 3, anticoagulation therapy. Pansentine, enteric aspirin, Chinese herbal medicine to activate blood circulation and remove blood stasis. 4.Improve microcirculation. Application of scopolamine. 5.Antibacterial therapy. Select the appropriate antibiotics according to the results of bacterial culture and drug sensitivity test. 6.Other therapies. Give neurotrophic agents, zinc supplementation of trace elements, hyperbaric oxygen therapy. 7.Toe amputation and (or) amputation surgery. 8.Arterial reconstruction surgery.