High gamma-glutamyltransferase is usually caused by physiological factors, or pathological factors such as liver disease and gallbladder disease. 1. Physiological factors: bad habits such as late night, tiredness, lack of sleep, overeating, smoking, drinking, mental stress, etc. will cause its value to rise. Generally, after improving these bad habits, the value can be reduced to normal. 2. Pathological factors: (1) Liver diseases: such as viral hepatitis, autoimmune hepatitis, cirrhosis, alcoholic liver, fatty liver, liver cancer, etc., may cause high gamma-glutamyl transferase. (2) Gallbladder diseases: such as cholecystitis, cholestasis, bile duct obstruction, gallbladder stones, bile duct stones, gallbladder cancer, etc., can also elevate its value. There may be other pathologic factors that lead to the elevation of this transaminase value, and you can consult a physician in the hospital to clarify the details and take appropriate measures.