There is a big difference between clinical cure and complete cure of hepatitis B, as follows: 1. Complete cure: the most important thing is that the surface antigen of hepatitis B turns negative, and the hepatitis B virus DNA is negative, liver function is completely normal, imaging examination is completely normal, and there are no symptoms, but it is difficult to achieve complete cure with the current medical level as well as medication. 2. Clinical cure: it is more common in the clinic, that is, the surface antigen of hepatitis B does not The hepatitis B virus DNA can be negative under the application of antiviral drugs, and all the symptoms and signs will disappear completely without any uncomfortable symptoms, and the laboratory biochemical examination, liver function index, jaundice index and transaminase index are completely normal, and no abnormalities are seen in the imaging examination. This clinical cure can be achieved by the current oral nucleoside analogues as well as interferon to modulate the immune antiviral therapy.