Syphilis stage 2 rash may appear as papules, macules, plaques, erythema, and nodules. The specific rashes are syphilis rash and flat warts. Stage 2 syphilis rash usually lacks specificity and may present as papules, macules, plaques, erythema, nodules, etc. It is often predominantly one type of rash, most of which are present in a generalized manner, and may or may not be accompanied by pruritic symptoms. A maculopapular syphilitic rash is characterized by a reddish maculopapular rash, or a yellowish-red maculopapular rash, similar to viral rashes and jock itch. Papular syphilis presents as a red papular, maculopapular rash that may be flaky or crusted. Syphilitic rash in the palmoplantar area presents as an infiltrative macular or maculopapular rash that is copper-red in color, about the size of a green pea to a soybean, often with collar-like flaking, and not fused to each other. Flat warts are oval and irregularly shaped, smooth-surfaced papules. Syphilis stage II can also manifest as arthritis, visual impairment and other conditions, need to timely hospitalization, follow the doctor’s instructions for treatment, avoid self-medication.