Kawasaki disease review of high cardiac enzymes may be due to concomitant myocardial damage, treatment is mainly based on drug therapy. Kawasaki disease is a vasculitis syndrome of undetermined etiology, can be complicated by myocardial damage, mainly due to coronary artery occlusion or stenosis, which in turn leads to elevated cardiac enzymes, and the treatment is mainly to receive antiplatelet aggregation, such as aspirin, and antianginal drugs, such as verapamil. When Kawasaki disease is combined with acute thrombosis of the coronary arteries and consequently elevated cardiac enzymes, thrombolytic drugs (urokinase, streptokinase, tissue plasminogen activator) or interventional therapy should be considered to open the blood vessels. When cardiac enzymes are elevated in Kawasaki disease, treatment should be directed by a physician, and the above medications need to be used as prescribed.