The reason why the plugged medication is usually effective is that the medication placed in the vagina is released under the effect of the local temperature of the vagina and is released in the posterior vaginal vault, thus killing the pathogens inside the vagina, and what comes out at this time is often the drug residue and vaginal and cervical secretions. In order to prevent all the medication from flowing out, it is usually recommended that women use the plugged medication at night before going to bed, as this will allow the medication to work longer in the vagina and be more effective. The next day, if the dregs come out, women must pay attention to the cleanliness and hygiene of the vulva, use water to clean the vulva, the next night you can put another pill.