If the mother is positive for HBsAg and HBeAg, the method of blockade should be combined with active and passive immunization. Hepatitis B immunoglobulin is the key to blockade and should be injected as early as possible after birth for early protection, preferably within 12 hours after birth at a dose of 200 units, along with 10 μg of recombinant yeast or 20 μg of Chinese hamster oocyte hepatitis B vaccine at different sites, and the second and third doses of hepatitis B vaccine at 1 month and 6 months of age, respectively; alternatively, one dose of hepatitis B immunoglobulin can be injected within 12 hours after birth, followed by the second dose of hepatitis B immunoglobulin one month later. The second dose of hepatitis B immunoglobulin can be administered within 12 hours of birth, followed by the second dose of hepatitis B immunoglobulin 1 month later, and a 10 μg recombinant yeast or 20 μg Chinese hamster oocyte hepatitis B vaccine at different sites, followed by the second and third doses of hepatitis B vaccine at 1 and 6 months intervals, respectively. One point to note is that when hepatitis B immunoglobulin and hepatitis B vaccine are given at the same time, they should be chosen to be given on different sides of the rump so as to avoid local neutralization of the vaccine (antigen) and the globulin (antibody).