For hypertensive patients with high blood potassium, thiazide diuretics should be chosen, avoiding potassium-preserving diuretics and angiotensin-converting enzyme inhibitors, etc. The most commonly used thiazide diuretics are hydrochlorothiazide. The antihypertensive effect of hydrochlorothiazide is mainly through sodium excretion, reducing the extracellular volume and thus lowering the resistance of peripheral blood vessels. Antihypertensive drugs such as hydrochlorothiazide have a relatively smooth and slow onset of action, with a long duration and long-lasting effect. Since thiazide diuretics can cause hypokalemia, they are particularly suitable for hypertensive patients with high blood potassium. Potassium-preserving diuretics including aminopterin and amiloride are strictly prohibited to be used in patients with high blood potassium because they can cause hyperkalemia due to the retention of potassium in the body; angiotensin-converting enzyme inhibitors such as captopril and angiotensin receptor blockers such as valsartan are also prohibited to be used in patients with high blood potassium because of the mild retention of potassium ions. If there is any physical discomfort, please consult a doctor in time, and the drugs should be rationally applied according to the doctor’s instructions.