Knee pain after long-distance running may be caused by lactic acid stimulation or joint wear and tear, etc. It can be recovered through adequate rest, physical therapy as well as medication. 1. Adequate rest: patients should first take adequate rest and braking, avoid strenuous exercise for a short period of time, reduce joint weight-bearing and elevate the affected limbs to prevent aggravation of knee pain symptoms. 2. Physical therapy: after exercise, you can immediately apply ice packs on the knee joint to reduce inflammatory exudation, reduce swelling and pain symptoms, and after 72 hours, you can take heat packs, ultrashort wave and other physical therapy to relax the local muscles, promote blood circulation and inflammatory absorption, which can improve the symptoms of knee pain. 3. Medication: If the pain is obvious, it is recommended that patients take ibuprofen, acetaminophen and other pain relieving medications under the guidance of a doctor to relieve pain symptoms. Long-distance running after knee pain patients such as pain is obvious, and the symptoms continue to do not relieve, should be considered whether there is ligament damage, meniscus injury or osteoarthritis may be, it is recommended that patients go to the hospital in a timely manner to consult the cause of the disease for standardized treatment.