What causes low prealbumin

1. Serum prealbumin is a serum protein synthesized by hepatocytes, whose main physiological function is to transport thyroxine and vitamins, and has thymic hormone activity, which increases the body’s immunity by promoting the maturation of lymphocytes.

2. Serum prealbumin is important for the diagnosis of clinical liver damage. The serum pre-albumin is one of the fast-transporting proteins produced by hepatocytes, with a daily catabolic rate of 33.1%-39.5% and a half-life of only 1.9 days, so this indicator reflects minor changes in hepatic synthesis and catabolic metabolism, and the magnitude of the decrease in serum concentrations correlates closely with the extent of parenchymal damage.

3. Prealbumin decreases rapidly in response to acute chronotropic reactions and is a negative acute chronotropic protein.

3. Serum prealbumin, a nonspecific host defense substance, clears toxic metabolites released in the circulation during infection and is gradually depleted, so it can be rapidly reduced during the acute phase response and is therefore a negative acute phase protein that can be used to identify bacterial or viral infections.