The hazards of high ASTE need to be analyzed according to the triggers, and different triggers have different hazards. 1. non-pathological factors: such as strenuous exercise and overwork, and excessive alcohol consumption, etc., may cause alanine aminotransferase elevation, this situation is not a liver dysfunction, so there is no obvious harm. 2. Pharmacological factors: for example, taking certain hepatotoxic drugs, including anti-tuberculosis drugs, such as rifampicin and isoniazid, etc.; such as antibiotics, including erythromycin and chloramphenicol, etc., may cause transient damage to the liver, and will return to normal after stopping the drug, which is generally not harmful to the liver. 3. Pathological factors: If viral hepatitis and other diseases triggered by alanine aminotransferase elevation, more harmful, may cause cirrhosis, or even liver cancer, must be actively treated. It is recommended that patients should first rule out other causes of ALT elevation, and actively seek treatment for ALT elevation induced by pathologic factors.