Mixed coronary plaque with mild lumen narrowing may be due to platelet adhesion and lipid aggregation, which can be treated with medications such as simvastatin and maintained with good lifestyle habits. Mixed coronary plaque refers to the presence of a mixture of calcified and non-calcified plaque in the coronary arteries and leads to stenosis. Non-calcified plaque is more prone to rupture, which leads to the formation of a local thrombus, which has the risk of blocking the coronary arteries and causing myocardial infarction, and requires active treatment. It is usually treated with antiplatelet aggregating drugs such as aspirin and lipid-lowering drugs such as simvastatin. These drugs may cause fatigue, nausea and other discomforts, and are contraindicated in patients with allergies, severe heart failure and active liver disease. Good lifestyle habits such as abstaining from smoking and alcohol, reducing the intake of fats and oils, etc., are also needed, and surgery can be used if necessary. The disease can be well controlled through systematic treatment, if diagnosed, please go to the hospital as soon as possible and according to the doctor’s instructions to avoid aggravation of the disease, if you need to use the drug, please follow the doctor’s instructions.