Ms. Wang is 33 years old and has been married for 3 years, but she has never had a child because of repeated miscarriages, which has dealt a huge blow to both her body and mind. On the recommendation of her obstetrician, she came to the Department of Rheumatology and Immunology for examination. It turned out that she was positive for antiphospholipid antibodies (ACL) and was diagnosed with antiphospholipid syndrome. After the efforts of the rheumatologist and obstetrician, Xiao Wang finally gave birth to a lovely baby this year. While she thanks her doctor, she would also like to remind young women who have experienced this before that “repeated miscarriages should alert you to antiphospholipid syndrome”. Anti-phospholipid syndrome (APS) is a group of syndromes characterized by morbid pregnancy (early miscarriage and mid- to late-term stillbirth), thrombosis, thrombocytopenia and other clinical manifestations with positive antiphospholipid antibodies. It is mostly secondary to autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, but can also exist alone. APS is most common in young people, with a male to female ratio of 1:9. APS is closely related to pregnancy. Patients may have one or more unexplained morphologically normal fetal deaths at or beyond 10 weeks of gestation. One or more morphologically normal fetuses at 34 weeks of gestation or less may be preterm due to severe pre-eclampsia or severe placental insufficiency. Unexplained spontaneous abortions occurring within 10 weeks of gestation on 3 or more consecutive occasions, except for maternal anatomic and endocrine abnormalities and parental chromosomal causes. It can also manifest as thrombocytopenia during recurrent pregnancies, either in periodic or acute episodes. In addition to this, it can also manifest as thrombocytopenia, recurrent deep vein thrombosis (inferior vena cava, retinal vein thrombosis). Cerebrovascular accident, limb gangrene, coronary artery thrombosis, retinal artery thrombosis, pulmonary hypertension, aseptic necrosis. Hemolysis, reticular cyanosis, migraine, chorea, epilepsy, chronic leg ulcers, endocardial disease, progressive dementia due to recurrent vascular thrombosis. Confirmation of APS requires serologic testing, including tests for autoantibodies such as lupus anticoagulants, anticardiolipin antibodies, and anti-β2-glycoprotein I (anti-β2-GPI antibodies), as well as blood and urine routines, sedimentation, renal function, and tests for antinuclear antibodies, anti-soluble nuclear antigen (ENA) antibodies, and other autoantibodies to rule out other connective tissue diseases. Patients with APS who are planning to become pregnant should be seen by the rheumatology and obstetrics departments prior to pregnancy to complete relevant antibody testing and assessment of pregnancy risk. In patients with recurrent habitual miscarriage in primary APS, the main focus is on symptomatic management, prevention of thrombosis and miscarriage recurrence. For secondary antiphospholipid syndromes, such as systemic lupus erythematosus, rheumatoid arthritis, and dry syndrome, active control of the primary disease is required, and pregnancy should be considered after the disease has stabilized. For antibody-positive pregnant women with recurrent miscarriages, anticoagulation therapy is required.