Many patients take entecavir dispersible tablets clinically cannot stop the drug at will, many patients take entecavir after the viral amount quickly appeared to decline, followed by normal liver function, many patients mistakenly think that the liver function is normal after the drug can be discontinued, but after discontinuation of the drug, the viral DNA again appear replication, sometimes will break the original immune balance of the immune reactivation state, so some patients will appear hepatitis damage aggravated phenomenon. For patients with liver disease who do not meet the criteria for discontinuation, they cannot stop the medication at will. Patients with cirrhosis of the liver should not stop taking the medication, but should take it for life to prevent the manifestation of severe hepatitis after stopping it. The time to stop taking entecavir is if the original non-cirrhotic hepatitis B patients, before the onset of major triple-positive, after taking entecavir viral DNA turned negative, surface antigen turned negative for more than 3 years can be considered to stop the drug, while the original patients are small triple-positive to take until the surface antigen turned negative to stop the drug.