Pain in the middle of the spine in the back is considered to be related to osteoporosis, degenerative spine disease, ankylosing spondylitis and other causes. It can be treated with general treatment, medication and surgery according to the cause. 1. Osteoporosis: it is a bone metabolism disease, which will reduce the amount of bone and destroy the microstructure of bone tissue, often involving the spine and joints, so it will cause pain in the middle of the spine. Attention should be paid to calcium supplementation, appropriate physical exercise, calcium carbonate, vitamin D and other treatments can be applied. 2. Degenerative spinal lesions: with age, degenerative spinal lesions, disc herniation, osteophytes and other changes can also cause pain in the middle of the spine. Non-steroidal anti-inflammatory drugs, such as celecoxib, can be applied to treat the pain, but also with heat therapy, electrotherapy, traction and other methods of treatment, to improve the symptoms can play a role. 3. Ankylosing spondylitis: a chronic inflammatory disease, mainly involving the spine, sacroiliac joints, etc., can also cause pain in the middle of the spine. Usually develop good habits, can apply non-steroidal anti-inflammatory drugs, such as celecoxib and other treatment. In the later stages of the disease, such as the emergence of severe spinal curvature, you can perform orthopedic spine surgery and other treatments. When there is pain in the middle of the spine in the back, you can go to the hospital to further identify the cause of the disease, and then targeted treatment. The above drugs need to be applied under the guidance of a physician.