The possible clinical causes of gastric distension after taking quadruple combination drugs include normal reaction after medication, improper diet and so on. 1. Normal reaction to the drug: there are two antibiotics in the quadruple combination of drugs, such as amoxicillin, clarithromycin, etc., which may appear after taking vomiting, nausea, diarrhea, abdominal pain and other gastrointestinal dysfunction symptoms, which belongs to the side effects of the drug, if the people who use the drug can tolerate it, then it should be continued to use the drug; if the side effects are more serious, it is necessary to stop taking the drug as soon as possible and to replace the new therapeutic drugs. 2. Improper diet: some people do not have a regular and healthy diet after using the drug, excessive overeating or eating spicy and stimulating food, such as cola, chili peppers, etc., will cause gastrointestinal tract stimulation and cause bloating and other symptoms. If side effects occur, you need to consult with the prescribing doctor and choose whether to continue or stop the medication through the doctor’s judgment.