Fever after the second dose of herpes zoster vaccine is mostly due to vaccine reaction, which is considered to be a normal phenomenon. The most common adverse reactions to vaccination are fever and redness, swelling and pain at the injection site, etc. If fever occurs, it usually resolves on its own within 2~3 days, and generally does not require special treatment, ordinary physical cooling can be used. If persistent fever or high fever does not go away, it is necessary to take appropriate treatment measures in time, under the guidance of the doctor to choose drugs for symptomatic treatment. During the treatment, increase the amount of water to promote metabolism, if the temperature is above 38.5 degrees, you can take ibuprofen, acetaminophen and other antipyretic drugs for symptomatic treatment. If the fever is recurrent, further examination is needed to see if there are other diseases causing the fever.