Adapalene gel is hormone-free. Adapalene gel is a retinoid with anti-inflammatory properties and is mainly indicated for the topical treatment of mild to moderate acne vulgaris with acne, papules and pustules as the main manifestation, and can also be used to treat acne on the face, chest and back. It can also be used to treat acne on the face, chest and back. It is applied once a day after washing the acne area before going to bed and applying a thin layer of the medication to the local lesions in spots. Care should be taken to avoid contact with the eyes and lips while applying the medication. It begins to work 4-8 weeks after treatment and shows significant improvement after three months. Common side effects of adapalene gel include causing dry skin, skin irritation, burning sensation and erythema. Adapalene gel is not recommended for use during pregnancy and treatment should be discontinued immediately for unplanned pregnancies and sun protection must be observed while using the medication.