Lupus erythematosus can have an effect on pregnancy and childbirth. If lupus erythematosus is non-remitting, patients are prone to miscarriage, premature birth or stillbirth, so contraception should be used. During the first trimester to gestation, if cyclophosphamide, methotrexate and azathioprine are applied, they can affect the growth and development of the fetus, and the above drugs must be stopped for at least three months before pregnancy can occur. Pregnancy can trigger the activity of lupus erythematosus, especially in early pregnancy and six weeks after delivery. Patients with a history of habitual abortion or positive antiphospholipid antibodies should take small doses of aspirin and small doses of glucocorticoids, such as prednisone 20-30 mg/d, which will be inactivated when passing through the placenta and will not harm the fetus. Lupus erythematosus can only be pregnant if there is no serious damage to the central nervous system, kidneys or heart and the disease is in remission for more than six months.