New crown vaccine first injection reaction is usually not very strong, in most cases is relatively mild, usually in 2 ~ 3 days to disappear, a small number of vaccinated people will appear local adverse reactions and systemic adverse reactions. 1. Local adverse reactions: the first injection of the new crown vaccine inoculants appear local adverse reactions, the vaccination site is more common adverse reactions have local skin redness, pain, itching, etc., and some people may also appear inoculation site swelling, pus and so on. 2. Systemic adverse reactions: after the first vaccination of the new crown vaccine, some of the inoculated may have generalized fatigue, high fever persists, abdominal pain, diarrhea, nausea and vomiting, loss of appetite and other systemic symptoms. Some allergic individuals may also experience discomfort such as skin rash with itching, and some may experience severe allergic reactions such as difficulty in breathing and fainting. After the first vaccination, you need to drink plenty of water, pay attention to rest, eat a light diet, avoid spicy food stimulation, avoid drinking alcohol and staying up late. If the adverse reaction is severe or lasts for a long time, it is recommended to consult a doctor and follow the doctor’s instructions to give appropriate treatment, so as to avoid delaying the condition.