Not all diabetic patients will develop diabetic nephropathy. After a large-scale epidemiological survey, about 30-40% of diabetic patients will lead to diabetic nephropathy, and once kidney damage occurs and clinical proteinuria appears, the condition will be difficult to reverse and eventually move toward the development of end-stage renal failure, which is life-threatening. Among the various complications of diabetes, nephropathy ranks third only after cardiovascular disease and neuropathy. Diabetic nephropathy is one of the main causes of death in diabetic patients. Therefore, the most important goal for diabetic patients is to prevent the appearance of kidney damage. So, under what conditions is diabetes prone to kidney damage? Risk factors for the development of diabetic damage include: 1. significant hypertension, especially elevated systolic blood pressure; significantly higher dosage of antihypertensive drugs than other patients; 2. high glomerular filtration rate, often exceeding 150 ml/min. especially after high protein intake; 3. glycated hemoglobin; 4. hypertriglyceridemia, hyper-LDLemia; 5. obesity (high body mass index ). Therefore, once diabetes is detected, blood glucose, blood pressure, lipids, weight and high protein food should be controlled as early as possible. To prevent the appearance of kidney damage.