For healthy people proper plasma donation has no obvious effect on the human body, but for people with low immunity and coagulation dysfunction, plasma donation may have an effect on the human body. 1. For healthy people, plasma donation will result in the loss of some of the solute components of blood, such as water, albumin, globulin, coagulation factors, inorganic ions, etc. These material components can be replenished in a relatively short period of time, which will have almost no effect on the human body. In addition, donate plasma do not donate too much, so as not to cause fatigue, low blood pressure and other phenomena due to too much blood donation. 2. For people with low immunity, the concentration of globulin in plasma will drop after plasma donation, which will lead to a decrease in immunity, which may affect the donor. 3. For patients with coagulation disorders, their coagulation disorders may be aggravated after plasma donation, making them more prone to bleeding and other related manifestations. Therefore, plasma donation is usually not recommended for people with low immunity and coagulation disorders, but for healthy people, appropriate plasma donation has no obvious effect on the body. The specific ability to donate needs to be evaluated by a medical professional.