A skin rash with fever may be a viral rash caused by a viral infection. Viral rash is not itchy, but also has other clinical manifestations such as fever, headache, and khat symptoms. It is recommended to seek medical advice to clarify the diagnosis and actively give treatment, and the rash can subside on its own. If there is a history of drug use before the rash appears, and the rash is itchy and intense, it may be a drug rash caused by drug allergy, which requires prompt discontinuation of the suspected drug, oral antihistamine, drinking more water to promote drug metabolism, and in severe cases, glucocorticoid systemic therapy. If there is no history of drug use and the rash is accompanied by itching, it may also be a rash caused by allergy. It is necessary to avoid contact with suspected allergens, avoid hot and cold stimulation, and take oral antihistamines for treatment.