Gray nails, or nail fungus, may be cured with only topical medications in the early stages of the infection or if the infection is mild. If the infection is severe, a combination of oral medications is usually needed, as prescribed by your doctor. Oral medications are usually recommended. Gray nails are nail lesions caused by fungal infections of the nail plate and underneath the nail. Topical antifungal drugs such as amorolfine and oral antifungal drugs such as itraconazole are the mainstay of treatment for gray nails. Patients with early stage of gray nail infection, or patients with lesser degree of infection, such as only the distal nail is infected, and the infected area is not more than 30% of the nail plate; there is no onychomycetous involvement; the number of affected fingers (toes) is relatively small, purely topical medication, there is a possibility of cure. In addition, the faster the nail growth rate, the better the efficacy of topical drugs, so topical drug treatment is more advantageous for children and young people with faster nail growth. Most patients cannot be cured with topical medications alone and require a combination of oral medications. The specific treatment should be evaluated and determined by a physician, and it is recommended to follow the doctor’s instructions.