There is no such thing as the best treatment for osteoarthritis of the knee clinically. Osteoarthritis treatment is a step-by-step treatment program based on the condition. Conservative treatment can be carried out in the early stage, and medication or surgery can be used for serious development. 1. Conservative treatment: When osteoarthritis is in its early stage and the joint pain is not serious, it is necessary to reduce the weight bearing on the joints, and you can ride a bicycle to reduce the load on the joints. You can do more straight leg raising exercises and squatting against the wall to increase muscle strength. 2. Medication: If there is joint wear and tear joint injection of sodium vitrate, nutritional cartilage, reduce joint pressure, you can also take oral glucosamine sulfate. Usually can do ultrasound physical therapy. Oral non-steroidal pain relieving and anti-inflammatory drugs such as celecoxib can also be taken for treatment. 3. Surgical treatment: If the joint pain, joint activity is limited, you can take arthroscopic cleaning or osteotomy orthopedic surgery. For serious deformation of the joints, which seriously affects daily life, artificial joint replacement surgery can be performed. Osteoarthritis needs to be evaluated in the hospital to take the best treatment plan.