Pain when walking on the fourth toe of the left foot is commonly caused by fractures, dislocations, soft tissue contusions, toe nerve inflammation, etc., as follows: First, fractures, dislocations or soft tissue contusions: fractures, dislocations or soft tissue contusions can cause painful toe symptoms when walking with weight, accompanied by limited activity and local swelling, and fractures or dislocations can be detected by taking X-rays. After timely repositioning and fixation, the pain symptoms can be relieved. Second, toe nerve inflammation: toe nerve in the process of walking by the compression of the surrounding tissue, can produce acute inflammation, the patient will show symptoms of toe pain when walking with weight, and at the same time have such as over inductance, will affect the patient’s normal life, even when rest will not have significant relief. After oral administration of anti-inflammatory drugs such as celecoxib and loxoprofen sodium, the nerve inflammation can be reduced and the pain symptoms can be completely relieved.