The main reasons for suffering from UTI include primary, secondary, and hereditary kidney diseases. Meanwhile, it also includes factors leading to progressive development of uremia and triggers of acute exacerbation. 1. Primary kidney disease: including glomerulonephritis, tubulointerstitial disease, renal vascular disease, chronic pyelonephritis, etc. 2. Secondary kidney disease: kidney damage secondary to systemic diseases mainly includes diabetic nephropathy, hypertensive kidney damage, allergic purpura nephritis, lupus nephritis and so on. 3. Hereditary kidney disease: hereditary nephritis, polycystic kidney with autosomal inheritance and so on. 4. Factors of progressive development: mainly including hyperglycemia, hypertension, proteinuria, hypoproteinemia, uremic toxin accumulation, etc. 5. Causes of acute exacerbation: such as failure to control severe hypertension, nephrotoxic drugs, urinary tract obstruction, severe infections and so on. There may be other causes of uremia, and it is recommended that patients go to regular hospitals in time and standardize their treatment under the guidance of doctors.