Itching inside the bone is a deep abnormal sensation, mostly due to nerve or bone lesions. The common causes of neuropathy are restless leg syndrome, which is a disease related to family genetics, mostly itchy leg bones at rest or suffocating discomfort, and the symptoms are relieved after walking or activity, and the location is often unclear. Another condition is bone lesions, common in growth and development or elderly patients with osteoporosis, may be related to abnormal calcium metabolism and deficiency, can be clearly diagnosed through blood ion analysis, if necessary, timely oral calcium preparations and vitamin D drug treatment, can gradually relieve this discomfort.