Hypertrophy of the transverse processes of the fifth lumbar vertebra and fusion with the sacrum is clinically known as lumbar sacralization, which may be due to congenital genetic factors, long-term strain, etc. The treatment mainly includes life modification, physical therapy and medication. 1. Congenital genetics: Patients with congenital asymptomatic lumbar sacral ossification usually do not need treatment. 2. Long-term strain: need to reduce bending labor and other actions, avoid prolonged standing and sedentary, lumbar muscle strength is weak patients can choose to wear a waist cushion; followed by heat therapy, massage, deep microwave and other treatments can be chosen to accelerate the local blood circulation, reduce the lumbosacral muscles of edema, tension. In addition, patients with pain can choose non-steroidal anti-inflammatory drugs such as indomethacin and ibuprofen; they can also choose topical Yunnan Baiyao, safflower oil, etc., to promote local blood circulation; for patients with obvious symptoms of edema, they can be treated with intravenous infusion of mannitol and other anti-swelling treatments. The above drugs need to be used under the guidance of a doctor, avoid self-medication. If the diagnosis of lumbar sacral ossification is confirmed, it is recommended to carry out standardized treatment as early as possible to reduce the adverse effects of the disease.