Pain at the root of the middle finger in the palm when pressed may be related to trauma and tendonitis. Traumatic injury to the metacarpophalangeal joint capsule of the middle finger or fracture of the proximal phalanx or metacarpal bone may cause pain when the root of the middle finger is pressed. When stenosing tenosynovitis of the flexor tendon occurs in the middle finger, the symptom of pain on pressure at the root of the middle finger in the palm can also occur, and at the same time, obvious hard nodules can be touched. When rheumatoid arthritis and gouty arthritis invade the metacarpophalangeal joints of the middle finger, there will also be pain when the root of the middle finger is pressed. If the symptoms of pain when pressed on the root of the middle finger of the palm, it is recommended that the patient go to the hospital in a timely manner to improve the examination, targeted treatment.