There is no best way to remove pigmented spots, different methods can be chosen according to the type of pigmented spots, such as freckles, chloasma mainly choose medicine and laser treatment; nevus of Ota mainly choose laser treatment and so on. 1. Freckles: mainly related to family heredity, manifested as brown spots on the face. Often choose medication, such as trichloroacetic acid solution, phenol and other chemical peeling drugs localized spot coating, which can make freckles peel off; laser treatment, such as ruby laser, emerald laser, intense pulse light and so on. 2. Melasma: mainly related to ultraviolet radiation, endocrine disorders, cosmetics, pregnancy and other factors, manifested as butterfly-shaped yellow-brown patches on the face. Drug treatment and laser treatment can be chosen according to the condition. (1) Drug treatment. Including topical drugs, such as hydroquinone cream, vitamin A acid, fruit acid and other drugs for stripping, decoloration; systemic drugs, such as vitamin C, vitamin E, tranexamic acid and other drugs orally, can relieve the symptoms. (2) Laser treatment. Such as low energy laser, intense pulsed light therapy (IPL), etc. 3. Nevus of Ota: related to heredity, manifested as blue-gray, gray-brown patches on the face. It is mainly treated by laser, such as ruby laser, emerald green gemstone laser, YAG laser, etc. All the above medicines should be used according to the doctor’s prescription. It is recommended to go to the hospital when pigmentation occurs, and treat according to the cause under the guidance of the doctor.