1. Mycoplasma pneumoniae negative means that the patient has not been infected with Mycoplasma recently. Mycoplasma is an atypical pathogen, and infection often causes Mycoplasma pneumonia, which is characterized by a persistent dry cough, and laboratory tests will show positive antibodies to Mycoplasma. 2. Mycoplasma pneumoniae antibodies are categorized into lgG and lgM, lgM type antibodies appear earlier and disappear earlier, representing the patient’s recent infection. If lgM antibodies are negative, it may be that there is no recent infection, or it may be that the infection is longer and the antibodies have disappeared; lgG antibodies appear later, and if they are negative, it may be that they are infected at an early stage. Therefore, it should be analyzed comprehensively. 3. If Mycoplasma pneumoniae antibody lgG and lgM are negative, Mycoplasma pneumoniae infection can be basically ruled out. If the patient has symptoms related to pneumonia, including coughing and sputum, dyspnea and other manifestations, other pathogens can be considered, including chlamydia, viruses, fungi and other infections. Negative antibodies to Mycoplasma pneumoniae can initially determine that there is no mycoplasma infection, but the specifics should be based on the patient’s clinical manifestations, imaging manifestations and other comprehensive judgment. If there is any symptom related to pneumonia, we should consult a doctor in time to find out the cause of the disease.