Causes of false positives for neocoronary antigens include the presence of interfering substances in the organism or problems with the specimen.
1. Interfering substances: For example, rheumatoid factor, lysozyme and heterophilic antibody complement may react with the new coronavirus antibody, which may affect the test result.
2. Specimen problems: such as hemolysis and incomplete coagulation of the specimen, as well as bacterial contamination of the specimen and prolonged storage of the specimen may cause problems with the specimen, leading to false positives when receiving the antibody test.
In addition, a positive antibody to novel coronaviruses is generally not a diagnostic basis for serologic testing, and a comprehensive diagnosis should be made that takes into account the patient’s clinical presentation, underlying disease, and epidemiologic history.
As with all immuno-methodological testing reagents, there is a probability of false-positive or false-negative non-specific binding of the reagent itself, similar to the fact that a single key can open several locks or a single lock can be opened by several keys.
Due to the limitations of the methodology itself, there are many influencing factors, and the problem of non-specificity is an unavoidable and common phenomenon in all immunoassays, so false positives or false negatives in the new crown antigen assay are objective and unavoidable.