An elevated cardiac enzyme profile in newborns is mainly indicative of cardiac pathology, such as myocarditis or myocardial injury. Myocardial enzymes are enzymes found in the myocardial tissue, so if they are elevated, myocardial tissue damage is the main concern. Ischemia and hypoxia, infections, and congenital myopathies can all increase the myocardial enzyme profile. If the symptoms of elevated cardiac enzymes in newborns are not severe, adequate rest and intensive care are needed, and the symptoms can be relieved with the use of myocardial nutrients. Commonly used myocardial drugs such as sodium fructose diphosphate, coenzyme Q10, vitamin C, vitamin B6, etc. should be used to treat myocardial enzymes.