It is not recommended to take quadruple therapy for H. pylori after 14 days of taking quadruple therapy and before review. For Helicobacter pylori infection, the current recommended first-line treatment regimen is quadruple therapy, i.e., two antibiotics + a proton pump inhibitor + a bismuth agent, such as amoxicillin, clarithromycin, omeprazole, and bismuth potassium citrate. For people with combined peptic ulcers, the proton pump inhibitor and bismuth can be extended up to one month, and smoking and alcohol are prohibited during the treatment period to prevent interference with the efficacy. Four Reversals is a Chinese herbal formula composed of Paeonia lactiflora, Citrus aurantium dulcis, Radix Bupleurum Chinense, Radix et Rhizoma Glycyrrhizae, and Radix et Rhizoma Glycyrrhizae, and it is indicated for gastric discomfort caused by liver, spleen and qi depressions, and it is recommended to use it under the guidance of professional doctor’s identification. The eradication of H. pylori requires a review of the effect 1 month after the end of treatment and discontinuation of medication. Taking other gastric medications during this period may affect the result of the review, so it is recommended not to take Sihui San before the review. It is not recommended to use drugs blindly during the period of H. pylori eradication and before the review. If you still have stomach discomfort, it is recommended to consult a professional doctor and choose drugs that will not affect the result of the review.